2-Carboxyalkyl-2,3-dihydro-6-mercapto-s-triazolo[4,3-b]-pyridazi

Details 2-Carboxyalkyl-2,3-dihydro-6-mercapto-s-triazolo[4,3-b]-pyridazi 2-Carboxyalkyl-2,3-dihydro-6-mercapto-s-triazolo[4,3-b]-pyridazi

1979-03-21

1980-04-15

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D48704

Patent

active

041985060

ABSTRACT:
Certain 7-acylamido-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on- 6-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-[o-(methylaminomethyl)phenylacetamido]-3-(2-carboxyalkyl-2,3-dihydro-s-t riazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.

REFERENCES:
patent: 3907786 (1975-09-01), Naito et al.
patent: 3994898 (1976-11-01), Hoehn et al.

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