2-[(Carboxy)(triphenylmethylamino)methyl]-5,5-dimethyl-3-thiazol

Details 2-[(Carboxy)(triphenylmethylamino)methyl]-5,5-dimethyl-3-thiazol 2-[(Carboxy)(triphenylmethylamino)methyl]-5,5-dimethyl-3-thiazol

1976-10-29

1978-01-03

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D27710

Patent

active

040666573

ABSTRACT:
The present invention discloses novel 6-acylamino-2,2-dimethyl-3-phosphonopenams and certain lower alkyl esters thereof possessing antibacterial activity, methods for their production, and intermediates therefor; the production comprises the steps of reacting 6-triphenylmethylamino-2,2-dimethylpenam-3-carboxylic acid with lead tetraacetate to form the corresponding 3-acetoxy compound, the latter is converted to .alpha.-triphenylmethylamino-5,5-dimethyl-3-thiazoline-2-acetic acid which is condensed with dimethyl phosphite to produce .alpha.-triphenylmethylamino-5,5-dimethyl-4(0,0-dimethylphosphono)-thiazol idine-2-acetic acid which is cyclized to 6-triphenylmethylamino-2,2-dimethyl-3-(0,0-dimethylphosphono)penam and the latter is subsequently deblocked and acylated.

REFERENCES:
patent: 3816445 (1974-06-01), Dubs et al.
patent: 3931208 (1976-01-01), Offermanns et al.

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