2-carboxy-3-cyano-4-aryl-pyrroles

Details 2-carboxy-3-cyano-4-aryl-pyrroles 2-carboxy-3-cyano-4-aryl-pyrroles

1989-05-09

1990-05-08

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548517, 548526, 548527, 548532, C07D40100, C07D40500, C07D20700

Patent

active

049239945

ABSTRACT:
A process for the preparation of a 3-cyano-4-arylpyrrole of the formula ##STR1## in which Ar is optionally substituted heteroaryl or aryl, which comprises (a) reacting an .alpha.-cyanoacrylic acid derivative of the formula ##STR2## in which R.sup.1 is amino or alkoxy, with an isocyanoacetic acid ester of the formula ##STR3## in which R.sup.2 is alkyl, in the presence of a base thereby to produce a .DELTA..sup.2 -pyrroline-2-carboxylic acid derivative of the formula ##STR4## in which X represents hydrogen or an equivalent of an inorganic or organic cation,

REFERENCES:
patent: 3367944 (1968-02-01), Umio et al.

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