Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-03-06
1993-02-16
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514252, 514241, 544298, 544295, 544296, 544238, 544216, C07D23936, A61K 31505
Patent
active
051871750
ABSTRACT:
The present invention is novel compounds which are 2-carbonyl substituted-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.
REFERENCES:
patent: 4708966 (1987-11-01), Loomans et al.
patent: 4810716 (1989-03-01), Connor et al.
patent: 4959503 (1990-09-01), Connor et al.
patent: 5077411 (1991-12-01), Connor et al.
Belliotti Thomas R.
Connor David T.
Kostlan Catherine R.
Miller Steven R.
Daignault Ronald A.
Ford John M.
Warner-Lambert & Company
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