2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids an

Details 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids an 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids an

1995-08-03

1996-11-26

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546167, 546170, 514311, C07D 4002, C07D21552, A61K 3147

Patent

active

055786090

ABSTRACT:
This invention relates to 2-carbocyclic and 2-heterocyclic quinoline-4-carbocyclic acid compounds, and salts thereof, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, and chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, in a mammal.

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N. P. Buu-Hoi and Lavit, J. Chem. Soc. 2412, 1956.
N. P. Buu-Hoi and Cagniant, Chem. Ber., 76, 1269, 1943.

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