2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydr o-1H

Details 2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydr o-1H 2-Carbobenzoxy-8-fluoro-5-(p-fluorophenyl-2,3,4,5-tetrahydr o-1H

1984-08-16

1986-02-04

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564 54, 564310, 546 86, C07D47104

Patent

active

045687480

ABSTRACT:
1,1-Di(p-fluorophenyl)urea, 2-carbobenzoxy-8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4, 3-b]indole, an efficient process for converting the former to the latter, further comprising conversion of the latter to 8-fluoro-5-(p-fluorophenyl)-2-[4-(p-fluorophenyl)-4-hydroxybutyl)-]2,3,4,5 -tetrahydro-1H-pyrido[4,3-b]indole (flutroline) or to 8-fluoro-5-(p-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (an alternative flutroline intermediate).

REFERENCES:
patent: 4001263 (1977-01-01), Plattner et al.
patent: 4014890 (1977-03-01), Welch
patent: 4224329 (1980-09-01), Welch
patent: 4267331 (1981-05-01), Welch
Harbert et al., J. Med. Chem., 23, pp. 635-643 (1980).
Murakami et al., Heterocycles 12, pp. 1571-1574 (1979).
Rylander, "Catalytic Hydrogenation Over Platinum Metals", Academic Press, 1967, pp. 291-303.

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