Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1986-08-21
1991-03-05
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
514210, C07D48704, A61K 3140
Patent
active
049979361
ABSTRACT:
Disclosed are 2- and 6-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein R.sup.6, and R.sup.7 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; A is a direct, single bond connecting the indicated S and C atoms, or A is a cyclic or acyclic connecting group selected, inter alia, from alkyl, cyclalkyl, aryl, heteroaryl, heteroalkyl; R.sup.1 and R.sup.2 inter alia, independently selected from hydrogen, alkyl, aryl; additionally, said carbamimidoyl is characterized by cyclic structures achieved by the joinder of the two nitrogen atoms via their substituents and by their joinder to connecting group A; additionally, "carbamimidiums" are disclosed by quarternization of one of the nitrogen atoms of said carbammidoyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharamaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
REFERENCES:
patent: 4309346 (1982-01-01), Christensen et al.
patent: 4309438 (1982-01-01), Christensen et al.
patent: 4312871 (1982-01-01), Christensen et al.
patent: 4335043 (1982-06-01), Christensen et al.
patent: 4341706 (1982-07-01), Christensen et al.
patent: 4347368 (1982-08-01), Christensen et al.
patent: 4552873 (1986-11-01), Myadra et al.
patent: 4696923 (1987-09-01), Christensen et al.
patent: 4720490 (1988-01-01), Mak et al.
Christensen Burton G.
Johnston David B. R.
Schmitt Susan M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rizzo Nicholas S.
Speer Raymond M.
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