2-butanol production method

Details 2-butanol production method 2-butanol production method

2008-05-13

2008-05-13

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C568S913000

Reexamination Certificate

active

11568905

ABSTRACT:
The invention relates to a process for the preparation of 2-butanol by enzymatic-catalyzed reduction of 2-butanone with a carbonyl reductase and a coenzyme and is characterized in that an aqueous phase, which contains the carbonyl reductase and the coenzyme, is contacted with an alcoholic phase, which is not miscible with the aqueous phase and contains 2-butanone, in order to reduce the 2-butanone, with the proviso that the alcohol present in the alcoholic phase is a secondary alcohol capable of regenerating the coenzyme and exhibiting a boiling point which lies above that of water, whereupon the 2-butanol formed is separated.

REFERENCES:
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patent: 5523223 (1996-06-01), Kula et al.
patent: 1 323 827 (2003-07-01), None
patent: 9318138 (1993-09-01), None
patent: 2004111083 (2004-12-01), None
patent: 2005049816 (2005-06-01), None

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