2-Bromo-6.beta.-fluoro-3-keto-.DELTA..sup.1,4 -steroids of the p

Details 2-Bromo-6.beta.-fluoro-3-keto-.DELTA..sup.1,4 -steroids of the p 2-Bromo-6.beta.-fluoro-3-keto-.DELTA..sup.1,4 -steroids of the p

1975-11-24

1980-02-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955R, 26023955D, C07

Patent

active

041894405

ABSTRACT:
Pregnane series steroids are disclosed having good anti-inflammatory and anti-rheumatoid arthritic activity with a decreased degree of side effects, e.g., weight loss and sodium retention. The compounds have the formula ##STR1## where X is a keto- or .beta.-hydroxyl group or chlorine, Y is fluorine or chlorine, Z is hydrogen, .alpha.-hydroxyl, .alpha.-methyl or .beta.-methyl, R' is hydrogen or a 2 to 8 carbon acyl group and R is hydrogen, a 2 to 8 carbon acyl group from mono- or di-carboxylic organic acids, a metasulfobenzoic acid residue or phosphoric acid residue.
When R' is hydrogen, and Z is .alpha.-hydroxyl the corresponding 16.alpha., 17.alpha.-acetonides and 16.alpha.-acyl derivatives with organic carboxylic acids having from 2 to 8 carbon atoms were prepared.

REFERENCES:
patent: 2813884 (1957-11-01), Bernstein
patent: 2815353 (1957-12-01), Fried
patent: 2838499 (1958-06-01), Spero

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