2.beta.-Substituted-methylpenicillanic acid derivatives, and sal

Details 2.beta.-Substituted-methylpenicillanic acid derivatives, and sal 2.beta.-Substituted-methylpenicillanic acid derivatives, and sal

1987-11-23

1990-01-02

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514195, 540310, C07D49900, A61K 31425

Patent

active

048913693

ABSTRACT:
Disclosed are 2.beta.-substituted-methylpenicillanic acid compounds of the formula ##STR1## wherein n is 0, 1 or 2; and ##STR2## is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.
These compounds are useful as .beta.-lactamase inhibitor.

REFERENCES:
patent: 4529592 (1985-07-01), Micetich et al.
patent: 4562073 (1985-12-01), Micetich et al.
patent: 4668514 (1987-05-01), Mictich et al.

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