2.beta.-substituted-6-alkylidene penicillanic acid derivatives a

Details 2.beta.-substituted-6-alkylidene penicillanic acid derivatives a 2.beta.-substituted-6-alkylidene penicillanic acid derivatives a

1998-12-29

2000-12-05

Berch, Mark L

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514195, 514196, 514197, 540310, C07D49987, A61K 3143, A61D 3104, C12N 999

Patent

active

061567450

ABSTRACT:
Compounds of formula I: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting .beta.-lactamase enzymes, for enhancing the activity of .beta.-lactam antibiotics, and for treating .beta.-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

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