2.beta.,19-ethylene bridged steroids as aromatase inhibitors

Details 2.beta.,19-ethylene bridged steroids as aromatase inhibitors 2.beta.,19-ethylene bridged steroids as aromatase inhibitors

1990-11-30

1992-11-24

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, 514182, 552510, A61K 31565, C07J 5300

Patent

active

051662019

ABSTRACT:
The present invention is directed to a group of androstane compounds which contain an ethylene radical bridging the 2- and 19-positions. These compounds are useful as aromatase inhibitors and they are prepared by the cyclization of a 19-[2-(4-toluenesulfonyloxy)ethyl]androst-4-ene-3,17-dione using a strong base.

REFERENCES:
patent: 4322416 (1982-03-01), Metcalf et al.
patent: 4902717 (1990-02-01), Senior et al.
Eggleston et al. Chemical Abstracts, vol. 109, 1988 Abstract 139666j.
Johnston et al., Endocrinology 115(2), 1984 pp. 776-785.
Lan-Hargest et al. Tetrahedron Letters, 28 (49) pp. 6117-6120, 1987.
Greway et al., Biochemistry International, 20, 591 (1990).
Burkhart et al., Steroids 45:357, 1985.

Affiliated with

Also associated with

Rating

2.beta.,19-ethylene bridged steroids as aromatase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2.beta.,19-ethylene bridged steroids as aromatase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2.beta.,19-ethylene bridged steroids as aromatase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-922034