2-Benzyl-4-piperidones useful as intermediates in the production

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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26029366, 26029383, 26029384, 424267, C07D21144, C07D22120

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active

040123928

ABSTRACT:
6,7-BENZOMORPHAN DERIVATIVES HAVING ANALGESIC AND MORPHINE-ANTAGONISTIC PROPERTIES ARE OF THE FORMULA ##STR1## in which the substituents R are either lower alkyl groups or groups which, together with the carbon atom to which they are bonded, form a cycloaliphatic ring, and the substituents R.sub.1, R.sub.2 and R.sub. 3 may or may not be made and, if made, R.sub.1 represents either a hydrogen atom or an alkyl, haloalkyl, alkenyl, alkinyl, aralkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl or cycloalkylidine-alkyl group, R.sub. 2 is an alkyl, aryl, heteroaryl or aralkyl group, and R.sub. 3 is a hydrogen atom or an hydroxy, alkoxy, alkoxy-alkoxy or acyloxy group. Such 6,7-benzomorphans may be in the form of their optically active enantiomers and/or their therapeutically acceptable salts. There are also disclosed methods for producing such 6,7-benzomorphan derivatives, and intermediates useful in such production.

REFERENCES:
patent: 3883536 (1975-05-13), Akkerman et al.
Teotino, J. Org. Chem. 27: 1906-1908 (1962).
Takeda et al., J. Org. Chem. 34: 4154-4160 (1969).

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