2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolem

Details 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolem 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolem

1994-06-01

1995-10-17

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514320, 514469, A61K 31535, A61K 31445, A61K 3134

Patent

active

054591392

ABSTRACT:
The synthesis and the biological evaluation of a series of basic ethers of 2-benzyl-3-arylbenzofurans as antitumor agents is described. These compounds bind significantly to the antiestrogen-binding sites but only poorly to the estrogen receptor sites and are cytotoxic to tumor cells. Some of these compounds also significantly inhibited de novo cholesterol biosynthesis in an estrogen receptor negative lymphoma cell line rich in antiestrogen-binding sites.

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