2-benzazepines with 5- and 6-membered heterocyclic rings to trea

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514217, A61K 3155

Patent

active

052100820

ABSTRACT:
Pharmaceutical compositions containing aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.

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de Montigny, Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers, Arch. Gen. Psychiatry, 46, (1989).
Dourish, et al., Morphine Induced Analgesia in the Rat Paw Pressure Test is Blocked by CCK and Enhanced by the CCK Antagonist MK-329, Eur. Jour. Pharm. 147, No. 3, pp. 469-472, (1988).
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