2-Azidomethyl-1,4-benzodiazepine compounds

Details 2-Azidomethyl-1,4-benzodiazepine compounds 2-Azidomethyl-1,4-benzodiazepine compounds

1982-06-08

1985-02-05

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239BD, 2602393D, 2602457, 2603303, 2603308, 2603309, 260465D, 260465E, 546272, 546298, 548537, 549 72, 549365, 549439, 549483, 560142, 564220, 564344, 564355, 424244, 424263, 424274, 424275, 424282, 424285, C07D40104, C07D40304, C07D40504, C07D40904

Patent

active

044977409

ABSTRACT:
New 2-acylaminomethyl-1H-2,3-dihydro-1,4-benzodiazepine compounds are described having the general formula I ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl or alkenyl radical or the cyclopropylmethyl radical, R.sub.2 is a hydrogen atom, or a lower alkyl or alkenyl radical, n is 0, 1 or 2, R.sub.3 is an optionally substituted furyl, thienyl, pyrrolyl, pyridyl or phenyl radical, R.sub.4 is an optionally substituted furyl, thienyl, pyrrolyl or pyridyl radical, R.sub.5 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoromethyl, cyano, amino, lower mono- or dialkylamino, lower monoalkanoylamino, lower N-alkyl-N-alkanoylamino or lower alkanoyloxy radical, and R.sub.6 is a hydrogen atom, or a lower alkyl or lower alkoxy radical or R.sub.5 and R.sub.6 together denote a methylenedioxy or ethylenedioxy radical. The compounds have pharmacological, for example, analgesic, properties.

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"Structure-Activity Relationships in the 1,4-Benzodiazepine Series": Drugs Affecting the Central Nervous System, pp. 237-240, 244-245, 256, 262.

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