2-Azasfiro[4.(3+N)]-3-carboxylic acid derivatives, a process for

Details 2-Azasfiro[4.(3+N)]-3-carboxylic acid derivatives, a process for 2-Azasfiro[4.(3+N)]-3-carboxylic acid derivatives, a process for

1983-03-25

1985-12-10

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548408, C07D20996, A61K 31395

Patent

active

045580642

ABSTRACT:
The invention relates to compounds of the formula I ##STR1## in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl cycloalkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R.sup.1 denotes an optionally protected radical of a naturally occurring amino acid HOOC--CH(NH.sub.2)--R.sup.1, R.sup.2 denotes hydrogen, alkyl or optionally nitro-substituted aralkyl, R.sup.3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiologically tolerated salts with acids and, if R.sup.2 and/or R.sup.3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.

REFERENCES:
Schroeder & Lubke, The Peptides vol. 1 (pp. IX, XIII-XXIV, 1, 2, 72-75, 246-270) (1965).
Eberle Perspectives in Peptide Chemistry, NY, 1981 (pp. 143-155).
Sybertz et al., Chem. Abs. 99, 82251p (1983).

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