Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2009-08-13
2010-12-07
Riley, Jezia (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C536S024300, C536S025300, C536S026600, C435S006120
Reexamination Certificate
active
07847075
ABSTRACT:
Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.
REFERENCES:
patent: WO 9202638 (1992-02-01), None
Seela et al. (Collection Symposium Series vol. 2 1999, 124-128).
Bergmann Frank
Heindl Dieter
Rosemeyer Helmut
Schweinberger Enno
Seela Frank
Kay Olga
Riley Jezia
Roche Molecular Systems Inc.
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