2-azacycloalkylthiopenem derivatives

Details 2-azacycloalkylthiopenem derivatives 2-azacycloalkylthiopenem derivatives

1984-09-13

1988-09-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514195, 540310, C07D49900, A61K 31425

Patent

active

047725974

ABSTRACT:
Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R is ##STR2## A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen, S(O).sub.m, or N--R.sub.3 ;

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S. Oida et al., Tetrahedron Letters, vol. 21, pp. 619-620 (1980).
M. Alpegiani et al., Heterocycles, 23, pp. 2255-2270 (1985).
G. Emmer et al., Jour. Antibiotics, XXXVIII, pp. 1371-1386 (1985).
G. Franceschi et al., Jour. Antibiotics, XXXVII, pp. 685-688 (1984).

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