2-arylquinolines and process for producing the same

Details 2-arylquinolines and process for producing the same 2-arylquinolines and process for producing the same

1997-01-24

1999-01-05

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 546118, 546173, C07D21518, A61K 3147, A61K 31475

Patent

active

058563377

ABSTRACT:
2-Arylquinolines represented by formula (1): ##STR1## wherein R.sup.1, R.sup.3 to R.sup.9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or --C.sub.m F.sub.2m+1 ; R.sup.2 represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy, --C.sub.n F.sub.2n+1 or --CH.sub.2 Q, in which Q represents a monovalent organic group obtained by eliminating from an organic compound having --NH-- the hydrogen atom bonded to the nitrogen, or halogen; X represents halogen or hydrogen; Y represents nitro or amino which may be protected with a protecting group; and m and n each represents an integer of from 1 to 6; and processes for producing the 2-arylquinolines.

REFERENCES:
Miyadera et al., "Studies on Quinolizinium Salts-VI.sup.1 the Reaction of Quinolizinium Ion with Aniline.sup.2 ", Tetrahedron 25:837-845 (1969).
Elderfield et al., "Synthesis of 2-Phenyl-4-Chloroquinolines", J. Am. Chem. Soc. 68:1272-1276 (1946).
Database Crossfire, Beilstein Informationssysteme GbmH; Frankfurt, DE; XP-002060234, (1997).
Database Crossfire, Beilstein Informationssysteme GmbH; Frankfurt, DE; XP-002020235 (1997).
Database Crossfire, Beilstein Informationssyteme GmbH; Frankfurt, DE; XP-002060236 (1997).
Database Crossfire, Beilstein Informationssysteme GmbH; Frankfurt, DE; XP-002020237 (1997).
Chemical Abstracts 110:8105, Reddy, abstract of Indian J Chem, Sect B, 1988, 27B(6), pp. 563-564.
Chemical Abstracts 110:135063, Atwell, abstract of J Med Chem, 1989, 32(2), pp. 396-401.
Chemical Abstracts 105:60452, Shaikah, abstract of J Med Chem, 1986, 29(8), pp. 1329-1340.
Chemical Abstracts 94:121454, Phillips, abstracts of J Heterocycl Chem, 1980, vol. 17(7), pp. 1489-1495.
Chemical Abstracts 86:29597, Lown, abstract of Dep Chem, Can J Chem, 1976, vol. 54(16), pp. 2563-2572.
Chemical Abstracts 70:96591, Miyadera, abstract of Tetrahedron, 1969, vol. 25(4), pp. 837-845.
Chemical Abstracts 106:119710, Atwell, abstract of EP 206802, Dec. 1986.
Chemical Abstracts 75:76768, Sheinkman, abstract of SU 301334, Feb. 1971.
Chemical Abstracts 74:76298, Sheinkman, abstract of Dopov Akad Nauk Ukr RSR, Ser. B, 1970, vol. 32(7), pp. 619-623.
Chemical Abstracts 100:6508, Haviv, abstract of US Patent #4407803, Oct. 1983.
Chemical Abstracts 96:162509, Chorbadzhiev, abstract of God Sofii Univ, Khim Fak 1981, vol. date 1977, 72, Pt 1, pp. 147-150.
Chemical Abstracts 87:167845, Hamana, abstract of Chem Pharm Bull, 1977, vol. 25(6), pp. 1256-1264.
Chemical Abstracts 84:134888, Badr, abstract of Can J Chem, 1975, vol. 53(24), pp. 3831-3836.
Chemical Abstracts 73:130926, Hamana, abstract of Fac Pharm Sci, Kyushu Univ, Fukuoka, Japan, Yakugaku Zasshi, 1970, 90(8), 991-1000.

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