Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-05-10
2011-05-10
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S523000
Reexamination Certificate
active
07939521
ABSTRACT:
The present invention relates to selected (R)-2-phenyl-propionamides and (R)-2-phenyl-sulfonamides with a hydrogen bond acceptor atom/group in a well defined position in the chemical space. These compounds show a surprising potent inhibitory effect on C5a induced human PMN chemotaxis. The compounds of the invention absolutely lack of CXCL8 inhibitory activity. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of sepsis, psoriasis, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion.
REFERENCES:
patent: WO-00/24710 (2000-05-01), None
patent: WO-01/58852 (2001-08-01), None
patent: WO-02/068377 (2002-09-01), None
Chinese Office Action issued Mar. 16, 2010, Appl. No. 200580048026.2.
New Zealand Office Action issued Jun. 19, 2009, Appl. No. 555502.
Russian Office Action issued Dec. 1, 2009, Appl. No. 2007126825/04(029201).
Pellas, T. C., “C5a Receptor Antagonists,” Current Pharma. Design, vol. 5, pp. 737-755 (1999).
Allegretti Marcello
Aramini Andrea
Beccari Andrea
Bertini Riccardo
Bizzarri Cinzia
Birch & Stewart Kolasch & Birch, LLP
DompePHA.R.MA S.p.A.
Solola Taofiq A
LandOfFree
2-arylpropionic acid derivatives and pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-arylpropionic acid derivatives and pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-arylpropionic acid derivatives and pharmaceutical... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2701836