2-arylbenzazole compounds

Details 2-arylbenzazole compounds 2-arylbenzazole compounds

1997-08-28

2000-03-07

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514321, 514367, 514375, 546198, 548178, 548179, 548180, 548217, 5482338, 424400, 424464, 424489, 424451, C07D27766, C07D26357, A61K 31425, A61K 3142

Patent

active

060342463

ABSTRACT:
There are disclosed herein 2-phenylbenzazole compounds having a 3'-substituent and a 4'-NR.sup.2 R.sup.6 substituent in the phenyl group where R.sup.5 and R.sup.6 are each hydrogen or alkyl, or where the $'-NR.sup.5 R.sup.6 substituent is N-acyl (or N-benzoyl). There are also disclosed 2-phenylbenzazole compounds in the form of 4'-N sulphamate salts. Such compounds exhibit significant selective cytotoxic activity in respect of tumor cells and provide potentially useful chemotherapeutic agents for selective treatment of a range of cancers.

REFERENCES:
patent: 2780628 (1957-02-01), Porter
patent: 3279918 (1966-10-01), Cassiers et al.
patent: 5371232 (1994-12-01), Bomba et al.
patent: 5496826 (1996-03-01), Watson et al.
patent: 5874431 (1999-02-01), Stevens et al.
Guellue et al, Bull. Soc. Chim. Belg., vol. 103(3), pp. 87 to 90, 1994.
Kanaoka et al, Chem. Pharm. Bull., vol. 18(3), pp. 587 to 590, 1970.
Rao et al, Indian J. Pharm. Sci., vol. 51(5), pp. 192 to 194, 1989.
Wolfbeis et al, Monatsh, Chem., vol. 114(5), pp 599 to 604, 1983.

Affiliated with

Also associated with

Rating

2-arylbenzazole compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-arylbenzazole compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-arylbenzazole compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-364539