2-arylamidothiazole derivatives with CNS activity

Details 2-arylamidothiazole derivatives with CNS activity 2-arylamidothiazole derivatives with CNS activity

1994-11-30

1996-04-23

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

544295, 544364, 544369, 546112, 546133, 548195, C07D27746, C07D41714, C07D41706, C07D45302

Patent

active

055104789

ABSTRACT:
The compound of the formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are, independently, H, alkyl, halo, perhaloalkyl, hydroxy, alkoxy, aryl or arylalkyl; n is an integer from 0-5; R is azabicyclo 2.2.2!octyl or azabicyclo 2.2.1!heptyl when n.sub.1 is zero, or R is NR.sub.4 R.sub.5 when n.sub.1 is 1, 2, 3, 4, or 5, in which R.sub.4 and R.sub.5 are alkyl or R.sub.4 and R.sub.5, taken with the nitrogen atom to which they are attached, are N-(substituted aryl)piperazinyl in which said substituent is alkoxy, halo, or perhaloalkyl; N-(pyridyl)piperazinyl; N-(pyrimidinyl)piperazinyl; or 3-azabicyclo- 3.2.2!non-3-yl; X is oxygen or NH; n and n.sub.1 are, independently, one of the integers 0, 1, 2, 3, 4 or 5; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.

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patent: 5324723 (1994-06-01), Baker et al.
K. Fukuda et al., TiPS 4-10 Dec. 1989 Supplement.
T. I. Bonner, TiPS 11-15 Dec. 1989 Supplement.
T. T. Soncrant et al., Psychopharmacology 112:421-427 (1993)**.
M. Williams, Curr. Opin. Invest. Drugs 2(5):541-544 (May 1993).
R. T. Bartus et al., Science 217:408-417 (Jul. 1982).

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