2-Aryl substituted isoxazolo(2,3-alpha)pyridinyl halides

Details 2-Aryl substituted isoxazolo(2,3-alpha)pyridinyl halides 2-Aryl substituted isoxazolo(2,3-alpha)pyridinyl halides

1976-05-27

1977-04-19

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424263, 260295F, 260296R, C07D49800

Patent

active

040187810

ABSTRACT:
2-Aryl substituted isoxazolo[2,3-a]pyridinyl halides having the formula I: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or lower alkanoyl; R.sub.4 is hydrogen or lower alkyl; X is a bromide, chloride or iodide salt; the pharmaceutically acceptable, acid addition salts thereof; and processes for the preparation thereof, are described. The compounds of the invention are useful as anti-inflammatory agents and for the treatment of hyperacidity.

REFERENCES:
patent: 3983237 (1976-09-28), Connor et al.
Boekelheide et al., J. Org. Chem. vol. 26, pp. 3802 to 3805 (1961).
Adams et al., J. Am. Chem. Soc. vol. 79, pp. 2236 to 2239 (1957).
Boekelheide et al., J. Am. Chem. Soc. vol. 80, pp. 2217 to 2220 (1958).
Osborne et al., J. Heterocyclic Chemistry, vol. 1, pp. 138 to 140 (1964).

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