2-Aryl-6-trifluoromethyl-4-pyridyl-carbinolamine antimalarials

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424266, C07D21326

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active

039534634

ABSTRACT:
A series of 2-aryl-6-trifluoromethyl-4-pyridylcarbinolamines is herein diosed which has value in treatment of plasmodial infections. The compounds have substituted phenyl groups at position 2- on the pyridine moiety, with the electronegative substituents present on the phenyl nuclei. The syntheses of such series is described, together with a method for separation of racemates of a representative 4-pyridylcarbinolamine type.

REFERENCES:
blumbergs et al., Chemical Abstracts 77:122111x, (1972).
Markovac et al., Chemical Abstracts 77:147450v, (1972).
La Montagne et al., Chemical Abstracts 78:92575c, (1973).
Shen et al., Chemical Abstracts 74:125442e, (1971).

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