2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as sel

Details 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as sel 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as sel

1979-09-06

1981-06-30

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548210, C07D27504

Patent

active

042762987

ABSTRACT:
The invention concerns novel 2-aryl-1,2-benzisothiazolinone-1,1-dioxide compounds; methods for their preparation; pharmaceutical compositions containing them as an active ingredient; and methods of inhibiting proteases, especially elastase, and of treating emphysema, rheumatoid arthritis, and various inflammatory diseases, for example, bronchial inflammation.

REFERENCES:
patent: 4006007 (1977-02-01), Bollinger
Bambas; Lewis L., "Chemistry of Heterocyclic Compound", vol. 4, pp. 330-339, Interscience Publishers, (1952).
Fischer; Rand H. Hurni, "Arzneitmittel Forschung ", 14, (12), 1301, (1964).
Stroud, "A Family of Protein-Cutting Proteins", Sci Am, Jul., 1974, pp.74-78.
Erichson, Acta. Med. Scand. 1964, 175, 197.

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