2- and 8-azido(2'-5')oligoadenylates and antiviral uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 48, 536 27, 536 28, C07H 1702

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049904981

ABSTRACT:
Compounds of the formula ##STR1##

REFERENCES:
Knowles, "Photogenerated Reagents for Biological receptor-Site Labeling," Acct. Chem Res. 5:155-160 (1972).
Hoyer et al., "The Use of Photoaffinity Probes to Elucidate Molecular Mechanisms of Nucleotide-Tegulated Phenomena," Ann. N.Y. Acad. Sci. 346:280-381 (1980).
Evans et al., "Photoaffinity Labeling of a Viral Induced Protein from Tobacco," J. Biol. Chem. 260:7800-7804 (1985).
Hegyi et al., "Photoaffinity Labeling of the Nucleotide Binding Site of Actin," Biochemistry 25:5793-5798 (1986).
Malkinson et al., "Changes in Pulmonary Adenosine Triphosphate-binding Proteins Detected by Nucleotide Photoaffinity Labeling Following Treatment of Mice With The Tumor-Modulatory Agent Butylated Hydroxytoluene," Biochemistry 25:5793-5798 (1986).
Garin et al., "Identification of Amino Acid Residues Photolabeled with 2-Azido [.alpha.-.sup.32 P] adenosine Diphosphate in the .beta. Subunit of Beef Heart Mitochondrial F.sub.1 -ATPase," Biochemistry 25:4431-4437 (1986).
Lundari et al., "Mapping of Nucleotide-depleted Mitochondrial F.sub.1 -ATPase wtih 2-Azido-[.alpha.-.sup.32 P] adenosine Diphosphate," J. Biol. Chem. 262:15172-15181 (1987).
Boulay et al., "Photoaffinity Labeling of Mitochondrial Adenosinetriphosphate by 2-Azidoadenosine 5'-[.alpha..sup.32 P]Diphosphate," Biochemistry 24:7372-7379 (1985).
Li et al., "2- and 8-AzidoATP: Photoaffinity Labelling of 2-5A Synthetase, Enzymatic Synthesis of 2- and 8-Azido Analogs of 2-5A for Use as Photoaffinity Probes of RNase L", J. Inter F. Res. 7:829 (Dec. 1987) (abstract).
Woody et al., "Characterization of a Photoaffinity Analog of UTP, 5- Azido-UTP for Analysis of the Substrate Binding Site of E. Coli RNA Polymerase," Biochim. Biophys. Res. Commun. 150:917-924 (Feb. 15, 1988).
Li et al., "2',5'-8-Azidoadenylate Trimer 5'-Triphosphate (2,5-8N.sub.3.rho.3 A.sub.3): Enzymatic Synthesis, Biological Properties and Photoaffinity Labelling of RNase L," Federation Proceedings 46:2084 (May 1, 1987) (abstract).

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