2 AND 3-Substituted-4-(heterocyclic-amino-sulfonyl)benzene sulfo

Details 2 AND 3-Substituted-4-(heterocyclic-amino-sulfonyl)benzene sulfo 2 AND 3-Substituted-4-(heterocyclic-amino-sulfonyl)benzene sulfo

1974-10-04

1976-08-10

Sutto, Anton H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260244R, 260333, C07D29514, C07D26534

Patent

active

039741559

ABSTRACT:
Compounds of the formulae: ##SPC1##
And the salts thereof with pharmaceutically acceptable cations wherein R.sup.1 is 3-trifluoromethyl, chloro, bromo or fluoro; n and m are each two or three; X is oxygen or sulphur; R.sup.2 and R.sup.3, when taken separately, are each hydrogen or alkyl having 1 to 4 carbon atoms; R.sup.2 and R.sup.3, when taken together, are alkylene having 2 to 4 carbon atoms; Y is methylene or a single bond; R.sup.4 and R.sup.5, when taken separately, are each hydrogen, hydroxy or alkoxy having 1 to 4 carbon atoms, and R.sup.4 and R.sup.5, when taken together, are oxo or alkylene dioxy having 2 to 4 carbon atoms, each oxygen atom in R.sup.4 and R.sup.5, when taken separately, and in R.sup.4 and R.sup.5, when taken together, being separated from the nitrogen atom of the heterocyclic ring by two or more carbon atoms, said compounds being cerebral vasodilators.

REFERENCES:
patent: 3165550 (1965-01-01), Holland et al.
patent: 3647873 (1972-03-01), Ziegler et al.
patent: 3709917 (1973-01-01), Ziegler et al.
Hayman et al., J. Pharm. Pharmacol, 14, pp. 451-455, (1962).

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