Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1991-04-19
1992-12-15
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 50, C07H 1900, C07H 2300
Patent
active
051718499
ABSTRACT:
There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron containing nucleoside compounds. Said carboranyl uridine nucleoside compounds exhibit enhanced lipophilicity and hydrophilic properties adequate to enable solvation in aqueous media for subsequent incorporation of said compounds in methods for boron neutron capture therapy in mammalian tumor cells.
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Barth et al., Cancer Research, vol. 50, pp. 1061-1070, Feb. 15, 1990.
Barth et al., "Boron Neutron Capture Therapy for Cancer", Scientific American, vol. 262, No. 10, 100-107, Oct. 1990.
Mishima et al., "Treatment of Malignant Melanoma by Selective Thermal Neutron Capture Therapy Using Melanoma-Seeking Compound", The Journal of Investigative Dermatology, vol. 92, No. 5, Supplement, May 1989, 321S-325S.
Heying et al., A New Series of Organoboranes. I. Carboranes from the Reaction of Decaborane with Acetylenic Compounds, Inorg. Chem. 1963, vol. 2, No. 6, 1089.
Barth et al., "Determination of Boron in Tissues and Cells Using Direct-Current Plasma Atomic Emission Spectroscopy", Anal. Chem., 1991, vol. 63, pp. 890-893.
Alam Fazlul
Anisuzzaman Abul K.
Barth Rolf F.
Soloway Albert H.
Tjarks Werner
Brown Johnnie R.
Foster Frank H.
The Ohio State University Research Foundation
Wilson J. Oliver
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