2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]

Details 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de] 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]

1990-04-16

1991-11-19

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544 59, 544 60, 540575, C07D41304

Patent

active

050668030

ABSTRACT:
2- and 3-Aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines , useful as analgesic agents, are prepared either by reaction of a 2- or 3-aminomethyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazine with an arylcarboxylic acid halide in the presence of a Lewis acid or by reaction of 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine with a 1-lower-alkyl-3-aryl-1,3-diketone or with a .beta.-aryl-.beta.-ketopropionaldehyde under dehydrating conditions and heating the resulting hydrazone in an acid medium.

REFERENCES:
Kurihara et al, Yakugaku Zasshi, 1986, 88(9), 1118-22, Chem. abs., vol. 70, 1969, Abstract 37748w.
Potter et al., J. Hetero. Chem., 9, 1972, 299-301.
Brennan and Saxton, Tetrahedron Lett. 26 (14), 1769-72 (1985).
Tetrahedron 43 (1), 191-205 (1987).

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