Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-05-03
1993-01-19
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540547, C07D26720, C07D28116, A61K 3155
Patent
active
051807203
ABSTRACT:
The present invention provides 2-, 3-, and 5- and/or 8-substituted, and/or side-chain substituted, dibenzoxazepine compounds of Formula I: ##STR1## wherein Y is sulfur, ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
REFERENCES:
patent: 3534019 (1970-10-01), Coyne et al.
patent: 3624104 (1971-11-01), Cusiz et al.
patent: 3917649 (1975-11-01), Mueller
patent: 3989719 (1976-11-01), Mueller
patent: 3992375 (1976-11-01), Mueller
patent: 4045442 (1977-08-01), Mueller
patent: 4125532 (1978-11-01), Mueller
patent: 4170593 (1979-10-01), Mueller
patent: 4559336 (1985-12-01), Mueller
patent: 4559337 (1985-12-01), Mueller
patent: 4614617 (1986-09-01), Mueller
Drower, et al., "The Antiociceptive Effects of Prostaglandin Antagonists in the Rat," European Journal of Pharmacology, 133, 249-256 (1987).
J. H. Sanner, "Dibenzoxazepine Hydrazides as Prostaglandin Antagonists," Intra-Science Chem. Rept., vol. 6, No. 1, 1-9 (1972).
K. Nagarajan, et al., "Synthesis of 10,11-Dihydrodibenz[b,f][1,4]oxazepine Derivatives as Potential Anticonvulsants & Psychotropic Agents," Indian Journal of Chemistry, vol. 24B, 840-844 (1985).
D. E. MacIntyre, et al., "Antagonism of Human Platelet Responses to Stimulatory and Inhibitory Prostaglandins," Prog. Lipid. Res. 20 (1-4), 453-9 (1981).
R. Gimet, et al., "Quantitative Determination of Polymorphic Forms in a Formulation Matrix Using the Near Infra-Red Reflectance Analysis Technique," J. Pharmaceutical & Biomedical Analysis, vol. 5, No. 3, 205-211 (1987).
J. H. Sanner, et al., "Structure-Activity Relationships of some Dibenzoxaepine Derivatives as Prostaglandin Antagonists," Advances in the Biosciences, 9, 139-148 (1972).
A. Rakovska, et al., "Antagonistic Effect of SC-19220 on the Responses of Guinea-Pig Gastric Muscles to Prostaglandins E.sub.1, E.sub.2 and F.sub.2," Arch. Int. Pharmacodyn., 268, 59-59 (1984).
W. E. Coyne, et al., "Anticonvulsant Semicarbazides," J. Med. Chem., 11(6), 1158-1160 (1968).
K. Gyires, et al., "The Use of the Writhing Test in Mice for Screening Different Types of Analgesics," Arc. Int. Pharmacodyn., 267, 131-140 (1984).
A. Bennett, et al., "Antagonism of Prostanoid-Induced Contractions of Rat Gastric Fundus Muscle by SC-19220, Sodium Meclofenamate, Iodomethacin or Trimethoquinol," Br. J. Pharmac., 71, 169-175 (1980).
C. A. Maggi, et al., "The Effect of SC-19220, a Prostaglandin Antagonist, on The Micturition Reflex in Rats," European Journal of Pharmacology, 152, 273-279 (1988).
George, et al., "Antagonism of Alcohol Hypnosis by Blockage of Prostaglandin Synthesis and Activity: Genotype and Time Course Effects," Pharmacology Biochemistry & Behavior, vol. 19, 131-136 (1983).
S. Nakajyo, et al., "Inhibitory Effect of Bassianolide, A Cyclodepsipeptide, on Drug-Induced Contractions of Isolates Smooth Muscle Preparations," Japan. J. Pharmacol., 3, 55-64 (1982).
A. Gomes, et al., "Pharmacodynamics of Venom of the Centipede Scolopendra subspinipes dehaani," Indian Journal of Experimental Biology, vol. 20, 615-618 (1982).
Hallinan E. Ann
Herin Marc
Husa Robert K.
Lesne Michel
Datlow Philip I.
G. D. Searle & Co.
Hastreiter Roberta
Matukaitis Paul
Shah Mukund J.
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