2-Aminothiazole allosteric enhancers of A 1 adenosine...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S150000, C514S366000

Reexamination Certificate

active

07485655

ABSTRACT:
The present invention relates generally to a class of 2-aminothiazole derivatives which have recently been identified as allosteric enhancers of the A1? adenosine receptor. These compounds, and therapeutic compositions containing them, are useful for treating conditions in which activation of the A1? adenosine receptor would be beneficial, for example, those conditions in which stimulation of angiogenesis would improve blood flow to ischemic tissues.

REFERENCES:
patent: 4877876 (1989-10-01), Tsuji et al.
patent: 5189049 (1993-02-01), Frehel et al.
patent: 6251922 (2001-06-01), Jahne et al.
patent: 6476059 (2002-11-01), Jähne et al.
patent: 6713638 (2004-03-01), Linden et al.
patent: WO 94/18212 (1994-08-01), None
patent: WO 99/42455 (1999-08-01), None
patent: WO 01/90092 (2001-11-01), None
Gupta, R et al, “Synthesis and antiinflammatory activity of some substituted 2-amino-8H-indeno[1,2-d]thiazoles,” Indian J. Pharmaceutical Sciences, 1991, pp. 245-248.
Esses-Reiter, K. et al, “Synthesis of C-nor-heterocyclic Steroid Analogs,” J. Heterocyclic Chem., 1996, vol. 33, No. 3, pp. 879-884.
International Search Report, corresponding to PCT/US03/01396, mailed on Jun. 5, 2003.
Gupta, R. et al., “Synthesis and Anti-inflammatory Activity of Some Substituted 2-amino-8H-indeno[1,2-d] thiazoles,” vol. 117, 111516b, Sep. 14, 1992, p. 857.
Gupta, R. et al., “Synthesis and Anti-inflammatory Activity of Some Substituted 2-amino-8H-indeno[1,2-d] thiazoles,” Indian Journal of Pharmaceutical Sciences, Jan. 30, 1991, pp. 245-248.
Chordia, M., et al., “2-Aminothiazoles: A New Class of Agonist Allosteric Enhancers of A1Adenosine Receptors,” Bioorganic & Medicinal Chemistry Letters 12, Apr. 16, 2002, pp. 1563-1566.
Satish Kumar, et al., “Condensed Heterocyclics: Part XVII - Synthesis of Dihydrophenanthrocarbazole, Dihydrophenanthrothiarole, dihydrophenanthroisoxazole 7 Dihydrophenanthropyrazole,” Indian J. Chem., vol. 21B, Jun. 1982, pp. 591-593.
European Search Report issued Jun. 24, 2008, 9 pages.
A.V. Naidu , et al., “Synthesis and Biological Activities of Substituted-1-Tetralone Derivatives: Part II,” Asian Journal of Chemistry, vol. 12, No. 3 (2000), pp. 687-692.
K. Ramalingam, et al., “Synthesis and Antimicrobial Activity of Azasteroid-Type Compounds and Related Systems. Effect of Hydrophilic and Lipophilic Groups on Activity,” Journal of Medicinal Chemistry, 1977, vol. 20., Nov. 5, pp. 664-669.
Klara Esses-Reiter, et al., “Synthesis of C-nor-Heterocyclic Steroid Analogues,” TIB Hannover, May-Jun. 1996, pp. 879-884.
Mitsuru Ohkubo, et al., “Studies on Cerebral Protective Agents. VIII. synthesis of 2-Aminothiazoles and 2-Thiazolecarboxamides with Anti-anoxic Activity,” Chem. Pharm. Bull. 43(9) 1497-1504 (Sep. 1995).
K. Darrell Berlin, et al., “Novel 2-Amino-4-Aryl-Substituted-and 2-Amino-4, 5-Disubstituted-Thiazoles,” Department of Chemistry, Oklahoma State Univ., Feb. 20, 1991, pp. 29-33.
V.F. Kucherov, “Amino Derivatives of the Heterocyclic Series. III. Polycyclic Analogs of Aminothiazole,” Zhurnal Obshschei Khimi 20, 1950, pp. 1658-1661.
Rebecca Brown, et al., “Biological Activity and Active Groups of Novel Pyrazoles, Thiosemicarbazones, and Substituted Thiazoles,” Proc. Oklahoma Acad. Sci., vol. 56, Jan. 1, 1976, pp. 15-17.
Abstracts From Purines 2001, p. 558.
Lingaiah Nagarapu, et al., “Synthesis of Phenylimidazo Thiazolo benzocycloheptene Derivates as Potential Antiinflammatory Agent - IV,” Indiana Institute of Chemical Technology, Hyderabad-500 007, India, vol. 7, No. 6, pp. 535-540.

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