2-Aminotetralin derivatives and process for producing the same

Details 2-Aminotetralin derivatives and process for producing the same 2-Aminotetralin derivatives and process for producing the same

1978-05-16

1980-12-16

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 65, 560 70, 560 71, 560 72, 560107, 2603403, 2603405R, 424282, 424308, C07C 6984

Patent

active

042399033

ABSTRACT:
Compounds, which have antispasmodic effects, represented by the following formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, an alkoxy group or, when taken together, R.sup.1 and R.sup.2 represent an alkylenedioxy group; R.sup.3 represents a hydrogen atom, an alkyl group or a cycloalkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, an alkoxy group, an alkyl group, a halogen atom, a hydroxyl group or, when two of R.sup.4, R.sup.5 and R.sup.6 are taken together, they represent an alkylenedioxy group; and A represents a straight or branched chain alkylene group having 2 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms and interrupted with an oxygen atom forming an ether bond therein, and the therapeutically useful acid-addition salts thereof; and a process for producing the same.

REFERENCES:
patent: 2112899 (1938-04-01), Lott et al.
Coles, Harold et al., "Local Anesthetics Containing the ac-Tetrahydro-beta-naphthylamine Pressor Group," J. Am. Chem. Soc., (1936), vol. 58, pp. 1989-1990.
McDermed, John D. et al., "Synthesis and Pharmacology of Some 2-Aminotetralins, Dopamine Receptor Agonists", J. of Medical Chem., (1975), vol. 18, (4), pp. 362-367.

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