2-aminoquinolinecarboxamides: neurokinin receptor ligands

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S148000, C546S149000, C546S168000, C546S169000, C544S363000, C514S233500, C514S253060, C514S299000, C514S307000, C514S313000, C514S314000, C206S828000

Reexamination Certificate

active

07041664

ABSTRACT:
Disclosed are compounds of the formula:or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof,wherein R1, R2, R3, X, Q1and Q2are defined herein,which compounds are ligands for neurokinin receptors, in particular NK-3 receptors, and are therefor useful in the treatment of a wide range of diseases or disorders including, but not limited to depression, anxiety, psychosis, obesity, pain, Parkinson's disease, Alzheimer's disease, neurodegenerative diseases, movement disorders, respiratory diseases, inflammatory diseases, neuropathy, immune disorders, migraine, biliary disfunction, and dermatitis.

REFERENCES:
patent: 5340822 (1994-08-01), Emonds-Alt et al.
patent: 5434158 (1995-07-01), Shah
patent: 6369053 (2002-04-01), Yuan et al.
patent: 0 512 901 (1994-04-01), None
patent: 53-44577 (1992-04-01), None
patent: WO 95/32948 (1995-12-01), None
patent: WO 96/02509 (1996-02-01), None
patent: WO 97/19926 (1997-06-01), None
patent: WO 97/19928 (1997-06-01), None
patent: WO 97/21680 (1997-06-01), None
patent: WO 98/41506 (1998-09-01), None
patent: WO 98/52942 (1998-11-01), None
Batt et al., Bioorg. Med. Chem. Lett., 1998, 8, pp. 1745-1750.
Boden, Phil et al., “Use of a Dipeptide Chemical Library in the Development of Non-Peptide Tachykinin NK3Receptor Selective Antagonists”,J. Med. Chem. 1996, 39, 1664-1675.
Buchwald et al. J. Org. Chem., 2000, 65, pp. 11444-11474.
Giardina et al., (1997) “Discovery of a Novel Class of Selective Non-Peptide Antagonists for the Human Neurokinin-3-Receptor. 1. Identification of the 4-Quinolinecarboxamide Framework”,Journal of Medicinal Chemistry, vol. 40, pp. 1794-1807.
Jacobs et al., Org. Synth. Coll., 1955, 3, pp. 456-458.
Lyle et al., J. Org. Chem. , 1972, 37, pp. 3967-3968.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-aminoquinolinecarboxamides: neurokinin receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-aminoquinolinecarboxamides: neurokinin receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-aminoquinolinecarboxamides: neurokinin receptor ligands will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3597486

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.