Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-01-18
1992-08-18
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514255, 514257, 514258, 544295, 544321, C07D40106, C07D40306, A61K 3153, A61K 31505
Patent
active
051400294
ABSTRACT:
2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and antihistaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects suffering from diseases and/or disorders associated with the release of neurotransmitters, in particular, a method of treating subjects suffering from sleep disorders with 2-aminopyrimidinone derivatives substituted with a 4-bis(aryl)methylene-1-piperidinyl group; and a method of treating subjects suffering from psychotic diseases and/or disorders with 2-aminopyrimidinone derivatives substituted with a 4-arylcarbonyl-1-piperidinyl, 4-benzazoyl-1-piperidinyl, 4-benzazolyl-1-piperazinyl or 4-indolyl-1-piperidinyl, 4-benzo[b]furanyl-1-piperidinyl or 4-benzo[b]thienyl-1-piperidinyl group.
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Dijk et al., Effects of seganserin, a 5-HT.sub.2 antagonist, and temazepam on human sleep states and EEG power spectra, European Journal of Pharmacology, 171 (1989) 207-218.
Idzikowski, The Effects of Ritanserin and Seganserin on Human Slow Wave Sleep, Proceedings of the International Symposium on Current Trends in Slow Wave Sleep Research, Beerse, Belgium, Jun. 25-27, 1987.
Boey Jozef M.
Kennis Ludo E. J.
Vandenberk Jan
Gupta Y. N.
Janssen Pharmaceutica N.V.
Metz Charles J.
Shah Mukund J.
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