Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-24
1994-02-08
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514255, 514257, 514258, 514243, 514256, 514263, 514279, 514281, 514295, 514320, 514321, 514184, A61K 31505, C07D23922, C07D48704
Patent
active
052848540
ABSTRACT:
2-Amino-pyrimidininone derivatives possessing serotonin-antagonistic and anti-histaminic properties. Compositions containing these compounds as the active ingredient. Method of treating subjects suffering from diseases and/or disorders associated with the release of neurotransmitters, in particular, a method of treating subjects suffering form sleep disorders with 2-aminopyrimidinone derivatives substituted with a 4-bis(aryl)methylene-1-piperidinyl group; and a method of treating subjects suffering from psychotic diseases and/or disorders with 2-aminopyrimidinone derivatives substituted with a 4-arylcarbonyl-1-piperidinyl, 4-benzazolyl-1-piperidinyl, 4-benzazolyl-1-piperazinyl or 4-indolyl-1-piperidinyl, 4-benzo[b]furanyl-1-piperidinyl or 4-benzo[b]thienyl-1-piperidinyl group.
REFERENCES:
patent: 4443451 (1984-04-01), Kennis et al.
patent: 4485107 (1984-11-01), Kennis et al.
patent: 4804663 (1989-02-01), Kennis et al.
Dijk et al. Eur. Journal of Pharmacology 171, 207-218, 1989.
Idzikowski, Proc. of the International Symposium on Current Trends in Slow Wave Sleep Research, 25-27, 1987.
Fissekis et al, J. Het. Chem., 13(4), 929-30, 1976.
Chemical Abstract 19, 19420S, 1968.
Boey Jozef M.
Kennis Ludo E. J.
Vandenberk Jan
Ford John M.
Gupta Y. N.
Janssen Pharmaceutica N.V.
Metz Charles J.
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