2-aminopyrimidine-4-carboxamide derivatives, their preparation a

Details 2-aminopyrimidine-4-carboxamide derivatives, their preparation a 2-aminopyrimidine-4-carboxamide derivatives, their preparation a

1991-10-01

1993-05-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544330, 544332, A61K 31505, C07D23902

Patent

active

052100863

ABSTRACT:
A compound which is a 2-aminopyrimidine-4-carboxamide derivative, of the general formula (I) ##STR1## in which m is 0 or 1,

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Daves, G., Jr. et al., "Pyrimidines. XIII. 2- and 6-Substituted 4-Pyrimidinecarboxylic Acids (la)", J. Het. Chem. (1964), 1, 130-133.
Boswell, Robert, Jr. et al., "Synthesis of Some N-Carboxylic Acid Derivatives of 3-Phenoxypyrrolidines, 4-Phenoxypiperidinies, and 3-Phenoxynortropanes with Muscle Relaxant and Anticonvulsant Activities", J. Med. Chem., 1974, vol. 17, No. 9.
Glennon, R. A. et al., "N-(Phthalimidoalkyl) Derivatives of Serotonergic Agents: A Common Interaction at 5-HT.sub.1A Serotonin Binding Sites?", J. Med. Chem, 1989, 32, 1921-1926.
Nishikawa, Y. et al., "Acrylamide Derivatives as Antiallergic Agents. I. Synthesis and Structure-Acitivty Relationships of N-[(4-Substituted 1-piperazinyl)alkyl]-3-(aryl and heteroaryl)acrylamides", Chem. Pharm. Bull. 37(1) 100-105 (1989).

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