2-aminopyridines as inhibitors of cyclooxygenase-2

Details 2-aminopyridines as inhibitors of cyclooxygenase-2 2-aminopyridines as inhibitors of cyclooxygenase-2

1998-09-11

1999-12-21

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514210, 514211, 514212, 5142222, 5142268, 5142278, 5142288, 5142355, 514340342, 514343, 514318, 540467, 540481, 540544, 540597, 544 3, 544 55, 544 60, 544 63, 544 96, 544124, 5462681, 5462704, 5462714, 5462784, 5462764, 546194, C07D21374, C07D40104, A61K 3144, A61K 3155

Patent

active

060049502

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
patent: 4757073 (1988-07-01), New et al.
patent: 5480568 (1996-01-01), Pawloski et al.
patent: 5593994 (1997-01-01), Batt et al.
patent: 5686470 (1997-11-01), Weier
Silverman, The Organic Chemistry of Drug Design and Drug Action, pp. 15-22, 1992.
New, J.S., et al., J. of Med. chem., vol. 31, No. 3, pp. 618-624, 1988.
Charushin, V. N., et al., J. Org. Chem., vol. 48, No. 16, pp. 2667-2671, 1983.

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