2-Aminopyrazines and the preparation of 2-aminopyrazines and pyr

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544336, 260465E, 2604655R, C07D24118, C07D24120

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active

045607567

ABSTRACT:
Novel 2-aminopyrazines and processes for the preparation of 2-aminopyrazines and pyrazines by reaction of an .alpha.-iminodiacetonitrile (a) with a hydrogen halide or (b) with an alcohol or a thioalcohol and a hydrogen halide or (c) with an alcohol or a thioalcohol in the presence of an alkali metal compound and/or an alkaline earth metal compound. The 2-aminopyrazines and pyrazines obtainable by the process of the invention are useful starting materials for the preparation of dyes, fungicides, bactericides, textile assistants, scents, folic acid derivatives, flavorings, and active ingredients in crop protection and drugs.

REFERENCES:
patent: 3607910 (1971-09-01), Wood et al.
Barot et al., J. C. S. Perkin I, (1973) pp. 606-612.
Murao et al., Chemical Abstracts, vol. 91 (1979) p. 762 Abstract 57537p.
Chem. Ber. 100 (1967) 560-563.
J. Amer. Chem. Soc. 90 (1968) 2424, 2425.
J. Org. Chem. 44 (1979) 1128-1130.
Ullmanns Encyklopadie der Technischen Chemie (4 Aufl.) 7, 385 and 20, 528, 529.

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