2-aminopurine derivatives

Details 2-aminopurine derivatives 2-aminopurine derivatives

2005-05-31

2005-05-31

Crane, L. E. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S026700, C536S027800, C514S04400A, C435S006120, C435S091500

Reexamination Certificate

active

06900307

ABSTRACT:
There are provided 2-aminopurine derivatives represented by the following general formula (1):where R represents any species selected from the group consisting of hydrogen and acyl groups, X represents any species selected from the group consisting of phosphoramidite and oligonucleotides, Y represents any species selected from the group consisting of dimethyltrityl groups and oligonucleotides, and Z1, Z2, Z3, Z4and Z5are the same or different and represent any species selected from the group consisting of hydrogen and hydroxyl, amino, lower alkyl, alkoxy, carboxyl and sulfonic acid groups, provided that Z1, Z2, Z3, Z4and Z5are not all hydrogen, as well as gene expression-regulating compositions characterized by comprising the derivatives. By introducing the 2-aminopurine derivatives into oligonucleotides it is possible to achieve crosslinking reaction with high reactivity for target nucleic acids and notably high base sequence specificity.

REFERENCES:
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patent: 9-124687 (1997-05-01), None
patent: WO 01/34619 (2001-05-01), None
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Nagatsugi et al. (II), “Synthesis and Cross-Linking of the Oligonucleotides Incorporating New Artifical Bases with Selective Reactivity to Cytidine,”Abstracts, Symposium on Biofunctional Chemistry, 12, 189-191 (1997);JICST File on Science Technology and Medicine in Japan,JST on STN as 980230686 (1998); only JICST abstract supplied.*
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