2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548218, 548476, 564 92, 564305, 546224, 514867, C07D20718

Patent

active

045337390

ABSTRACT:
This invention relates to the novel use of certain aromatic substituted amidines as antidiarrheals.

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C. J. Niemegeers, F. M. Lennerts, and P. A. Janssen, "Diphenoxin, the Active Ingredient of Diphenoxylate", Arzneim-Forsch., 22, 516-518, (1972).
H. J. Binder, "Net Fluid and Electrolyte Secretion . . . ", in Mechanisms of Intestinal Secretion, edited by H. J. Binder, New York: Alan R. Liss, 1979, pp. 1-16.
H. I. Jacoby and C. H. Marshall, "Antagonism of Cholera Enterotoxin by Anti-Inflammatory Agents in the Rat", Nature, (London), 235, 163-165, (1972).
R. A. Fisher, "Principles of Statistical Estimation", in Statistical Methods for Research Workers, 14th edn., Hafner, New York, pp. 301-339.
J. Berkson, "A Statistically Precise and Relatively Simple Method of Estimating the Bioassay with Quantal Response on Logistic Function", J. Am. Stat. Assn., 48, 565-599, (1953).

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