2-aminomethyl-chromans

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514454, 549407, 549340, 549387, A61K 31335, C07D31920

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active

053189884

ABSTRACT:
Aminomethyl-chromans are obtained by alkylation of correspondingly substituted amines or by reductive amination of correspondingly substituted aldehydes. The aminomethyl-chromans can be used as active compounds in medicaments, in particular for the treatment of diseases of the central nervous system.

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Ram Pratap, Indiana Journal of Chemistry, 11 May 1981, pub. Dec. 1981, pp. 1063-1067.
W. U. Dompert, Naunyn-Schmiedeberg's Arch Pharmacol, 1985, pp. 467-470.
Eckard Weber, Proc. Natl. Acad. Sci. USA, vol. 83, Nov. 1986, pp. 8784-8788.
Michael P. Kavanaugh, Proc. Natl. Acad. Sci., Apr. 1988, pp. 2844-2848.
W. Clark Still, J. Org. Chem., 1978, pp. 2923-2927.

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