2-Aminomethyl benzimidazole derivatives

Details 2-Aminomethyl benzimidazole derivatives 2-Aminomethyl benzimidazole derivatives

1974-06-20

1976-06-08

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602475EP, 2603092, 424248, 424267, 424273, C07D40106

Patent

active

039622568

ABSTRACT:
Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.

REFERENCES:
patent: 3758459 (1973-09-01), Fauran et al.

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