2-Aminomethyl-6-sulfamoylphenol derivatives with salidiuretic ac

Details 2-Aminomethyl-6-sulfamoylphenol derivatives with salidiuretic ac 2-Aminomethyl-6-sulfamoylphenol derivatives with salidiuretic ac

1987-09-23

1988-08-23

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C14380

Patent

active

047662417

ABSTRACT:
The invention relates to 2-aminomethylphenols of the formula I ##STR1## in which R.sup.1 and R.sup.2 represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or benzyl which is optionally substituted by alkyl, alkoxy or halogen, R.sup.3 and R.sup.5 denote hydrogen, halogen, alkyl or alkoxy, R.sup.4 denotes halogen, alkyl or cycloalkyl and R.sup.6 and R.sup.7 represent hydrogen or alkyl, it being possible for the radicals R.sup.1 and R.sup.2, R.sup.6 R.sup.7 and/or two of the radicals R.sup.3, R.sup.4 and R.sup.5 to form an alkylene chain which is optionally substituted by methyl groups and which, in the case of the radicals R.sup.1, R.sup.2, R.sup.6 and R.sup.7, can also be interrupted by oxygen atoms, sulfur atoms and/or imino groups, and to physiologically acceptable salts thereof, a process for their preparation, and their use and to pharmaceutical formulations based on these compounds.

REFERENCES:
Stokker, et al., J. Med. Chem., 1980, 23, 1414-1427.
Patent Abstracts of Japan, vol. 3, No. 87, 1979; p. 41, C 53 8 JP A- 54 63048.

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