2-aminoindane analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C562S433000

Reexamination Certificate

active

07034055

ABSTRACT:
The present invention relates to therapeutically active 2-aminoindane analogs of formula (I):Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. The novel compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.

REFERENCES:
patent: 3532744 (1970-10-01), Fletcher, III et al.
patent: 3704312 (1972-11-01), Russell et al.
patent: 3746495 (1973-07-01), Malis et al.
patent: 4291050 (1981-09-01), Woltersdorf
patent: 4500713 (1985-02-01), Suh et al.
patent: 4775695 (1988-10-01), Cragoe, Jr. et al.
patent: 5011472 (1991-04-01), Abischer et al.
patent: 5023252 (1991-06-01), Hseih
patent: 5321032 (1994-06-01), Matsuo et al.
patent: 5329049 (1994-07-01), Weisse et al.
patent: 5360936 (1994-11-01), Weisse et al.
patent: 5916920 (1999-06-01), Fernandez et al.
patent: 5948807 (1999-09-01), Efange et al.
patent: 2041655 (1971-03-01), None
patent: 77122 (1986-05-01), None
patent: 0 189 203 (1986-07-01), None
patent: 0451 753 (1991-10-01), None
patent: 0 515 681 (1992-12-01), None
patent: 0 807 621 (1997-11-01), None
patent: 1179060 (1970-01-01), None
patent: 1313429 (1973-04-01), None
patent: WO 91/12266 (1991-08-01), None
patent: WO 92/11858 (1992-07-01), None
patent: WO 93/08799 (1993-05-01), None
patent: WO 94/15917 (1994-07-01), None
patent: WO 94/15924 (1994-07-01), None
patent: WO 96/15099 (1996-05-01), None
patent: WO 96/15100 (1996-05-01), None
patent: WO 96/16081 (1996-05-01), None
patent: WO 97/09346 (1997-03-01), None
patent: WO 97/30992 (1997-08-01), None
patent: WO 98/51687 (1998-11-01), None
Pinder et al, Journal of Medicinal Chemistry, 2-Aminoindan-2-carboxylic Acids. Potential Tyrosine Hydroxylase Inhibitors, 1971, 14 (9), pp. 892-893.
Adham, N. et al., Proc. Natl. Acad. Sci., 1993, 90:408-412.
Akiyama et al., Brain Res., 1992, 569:71-77.
Aramori and Nakanishi, Neuron, 1992, 8:757-765.
Bashir et al., Nature, 1993, 363:347-350.
Blair, I. et al., Aust. J. Chem., 1979, 32:1055-65.
Brabet et al., Neuropharmacology, 1995, 34:895-903.
CA:95:61830 abs of Journal of Institution of Chemists (India) Gautam et al., 53(1):27-29 (1981).
CA:125:114326 abs of WO9615099 May 1996.
CA:129:343698 abs of Peptides 1996 symposium Proceedings of European Peptide Symposium by Lehmann et al., 24th Edinburgh Sep. 8-13 pp. 573-574 (1996).
CA:130:177836 abs of Neuropharmacology by Thomsen et al 37(12) pp 1465-73 (1998).
CA:135:132201 abs of Experimental Neurology by Faden et al 167(2) pp 435-44 (2001).
CA:135:267255 abs of WO2001072291 Oct. 2001.
CA:136:310133 abs of Chinese Journal of Chemistry by Ding et al. 19(12) pp 1232-8 (2001).
Cannon, J. et al., J. Med. Chem., 1974, 17(5):565-8.
Chemical Abstracts, vol. 110, No. 15, Apr. 10, 1989 (Aboul-Enein, M.N. et al., Sci. Pharm., 1988, 56:243-250).
Chemical Abstracts, vol. 118, No. 1, Jan. 4, 1993.
Chemical Abstracts, vol. 119, No. 15, Oct. 11, 1993 (JP5085999).
Chemical Abstracts, vol. 122, No. 21, May 22, 1995.
Chemical Abstracts, vol. 124, No. 5, Jan. 29, 1996 (Yang C., et al., J. Chem. Soc., Perkin Trans. I, 1995, 879-887).
Chemical Abstracts, vol. 81, No. 7, Aug. 19, 1974 (Cymerman Craig, J. et al., J. Org. Chem., 1974, 39(12):1669-1676).
Chiamulera et al., Eur. J. Pharmacol., 1992, 216:335-336.
Deeks, T. et al., J. Med. Chem., 1983, 26(5):762-5.
Deeks, T. et al., J. Pharm. Sci., 1984, 73(4):457-60.
Desai, M.A. and Conn, P. J., Neuroscience Lett., 1990, 109:157-162.
Eaton, S. A. et al., Eur. J. Neuroscience, 1993, 5:186-189.
Gavuzzo, E. et al., Int. J. Pept. Protein Res., 1991, 37(4):268-76.
Grouiller, A. et al., Eur. J. Med. Chem.—Chim. Ther., 1980, 15(2):139-46.
Hayashi et al., J. Neurosci., 1994, 14:3370-3377.
Hayashi et al., Nature, 1993, 366:687-690.
Hayashi, Y. et al., Br. J. Pharmacol., 1992, 107:539-543.
Hsieh, Kun-Hwa et al., J. Med. Chem., 1979, 22(9):1038-44.
Josien H., J. Med. Chem., 1994, 37:1586-1601.
Knopfel et al., J. Med. Chem., 1995, 38:1417-1426.
Koh et al., Proc. Natl. Acad. Sci. USA, 1991, 88:9431-9435.
Leftheris, K. et al., J. Med. Chem., 1996, 39(1):224-36.
Linden et al., Neuron, 1991, 7:81-89.
Ma et al., Journal of Organic Chemistry, 64:120-125, published on the Web Dec. 11, 1996.
Mendel, D. et al., J. Am. Chem. Soc., 1993, 115(10):4359-60.
Moreno-Manas, M. et al., Liebigs Ann., 1995, 10:1807-14.
Mosberg, H. et al., J. Med. Chem., 1994, 37(25):4371-83.
Norris, R. et al., Phytochemistry, 1975, 14:393-6.
Obrecht, D. et al., Helv. Chim. Acta, 1992, 75(5):1666-96.
Palacin, S. et al., J. Am. Chem. Soc., 1997, 119(49):11807-11816.
Palmer, E., Monaghan, D.T. and Cotman, C.W., Eur. J. Pharmacol., 1989, 166:585-587.
Pellicciari et al., J. Med. Chem., 1995, 38:3717-3719.
Prelog, V. and Helmchen, G., Angew. Chem. Int. Ed. Engl., 1982, 21:567-583.
Sacaan and Schoepp, Neuroscience Lett., 1992, 139:77-82.
Sacaan et al., J. Neurochemistry, 1992, 59:245-251.
Sarges, R. et al., J. Med. Chem., 1988, 31(1):230-43.
Schiller, P. et al., J. Med. Chem., 1991, 34(10):3125-32.
Schoepp, D., Trends in Pharmacological Science, 1990, 11:508-515.
Schoepp and Conn, Trends in Pharmacological Science, 1993, 14:13-20.
Schoepp, D.D. and Johnson, B.G., J. Neurochemistry, 1989, 56:1865-1913.
Schoepp, D.D. et al., J. Neurochemistry., 1991, 56:1789-1796.
Tanabe et al., J. Neurosci., 1993, 13:1372-1378.
Tanabe et al., Neuron, 1992, 8:169-179.
Taylor, J. et al., J. Med. Chem., 1970, 13(6):1226-7.
Thomsen, C. et al., Eur. J. Pharmacol., 1992, 227:361-362.
Thomsen, C. and Suzdak, P., Eur. J. Pharmacol., 1993, 245:299-301.
Thomsen, C. et al., J. Neurochem., 1993, 63:2038-2047.
Tovey et al., Clinica Chimica Acta, 1974, 56:221-234.
Weinshank, R.L., et al., Proc. Natl. Acad. Sci. (USA), 1992, 89:3630-3630.
Wickelgren, I. Science, 1998, 280:2045-2047.
Zheng and Gallagher, Neuron, 1992, 9:163-172.
Zon, J. et al., Liebigs Ann. Chem., 1992, 6:625-628.
Roger M. Pinder et al.; 2-Aminoindan-2-Carboxylic Acids; Potential Tyrosine Hydroxylase Inhibitors, Journal of Medicinal Chem. vol. 14, No. 9, 1971, pp. 892-893.
R. Lohmar et al. Alpha-Aminosauren als Nukleophile Acylaquivalente, IV, Synthese Symmetrischer Ketone unter Verwendung von 2-Phenyl-2-oxazolin-5-on Chemische Berichte, vol. 113, 1980, pp. 3706-3715.
Rudolf Knorr et al. Azomethine, 1-Azaally-Anionen und Metastabile sek., Enamine Chemnische Berichte, vol. 113, 1980, pp. 2462-2489.
Chemical Abstracts, vol. 58, No. 13, Jun. 24, 1963, Columbus, Ohio.
A.B. Mauger et al. Aryl-2 Halogenoalkylami nes—XX, Biochemical Pharmacology, 1962, vol. 11, pp. 847-858.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

2-aminoindane analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-aminoindane analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-aminoindane analogs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3616910

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.