Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1976-11-12
1979-03-20
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
260239A, 546205, 546216, 546222, 546229, 546233, 546234, 546240, 546238, 546239, 26037633, 2603764, 260558A, 424244, 424250, 424267, 424 32, 544400, 544402, 544401, 544399, 548335, 548336, C07D20706, A61K 3140
Patent
active
041454359
ABSTRACT:
Cis- and trans-N-(2-aminocycloaliphatic)-2-arylacetamide derivative compounds of the formula ##STR1## N'-dimethylamino)cyclohexyl!-N-methyl-2-(4-bromophenyl)acetamide and 2-(3,4-dichlorophenyl) and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and the preferred compounds have in addition only low to moderate apparent physical dependence liability, compared to morphine and methadone. As analgesics they would be useful also as antitussives. Processes for preparation of these compounds are also disclosed. This invention also includes compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in humans and animals, as well as methods for alleviating pain in animals and humans with these compositions.
REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 3647804 (1972-03-01), Rynbrandt et al.
patent: 3772308 (1973-11-01), Krapcho
patent: 3852347 (1974-12-01), Krapcho
Winternitz et al; Societe Chemique de France Bulletin, Series 5, 23, pp. 382-391 (1956).
Harper et al; J. Chem. Soc. (London) pp. 4280-4284 (1964).
Brittain et al, But. J. of Pharm. vol. 49, pp. 158-159 (1973).
Lee Mary
Reynolds John T.
Rizzo Nicholas S.
The Upjohn Company
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