2-aminocarbonyl substituted piperazine or diaza-cyclic...

Details 2-aminocarbonyl substituted piperazine or diaza-cyclic... 2-aminocarbonyl substituted piperazine or diaza-cyclic...

2011-04-26

2011-04-26

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S390000, C540S575000, C514S211080

Reexamination Certificate

active

07932255

ABSTRACT:
The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates or pharmaceutically acceptable formulations thereof. These compounds may be used to modulate cellular proliferation and to prevent and/or treat proliferative diseases.

REFERENCES:
patent: WO 99/47545 (1999-09-01), None
patent: WO 02/080895 (2002-10-01), None
patent: WO 02/080895 (2002-10-01), None
patent: WO 2004/005248 (2004-01-01), None
Rossen, et al., Asymmetric Hydrogenation of Tetrahydropyrazines: Synthesis of (S)-Piperazine-2-tert-butylcarboxamide, an Intermediate in the Preparation of the HIV Protease Inhibitor Indinavir, Tetrahedron Letters, vol. 36, No. 36, pp. 6419-6422 (1995).
Kim, et al., Apicidin Potentiates the Imatinib-induced Apoptosis of Bcr-Abl-positive Human Leukaemia Cells by Enhancing the Activation of Mitochondria-dependent Caspase Cascades, British J. of Haematology, 124 166-178 (2004).
Kipp, Rachael A. et al., “Molecular Targeting of Inhibitor of Apoptosis Bases on Small Molecule Mimics of Natural Binding Partners”, Biochemistry, 41(23)7344-7349(2002), American Chemical Society, Easton, PA, US.

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