Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-07-03
1992-11-24
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548469, 548491, 548494, 548503, C07D20904, A61K 3134
Patent
active
051661705
ABSTRACT:
There are disclosed various compounds depicted by the general formula, ##STR1## where the parameters X, Y, R.sub.1, R.sub.2, and R.sub.3 are as defined in the specification. These compounds are disclosed as topical antiinflammatory agents useful for the treatment of various skin disorders including exogenous dermatitis, endogenous dermatitis, dermatitis of unknown etiology and other cutaneous disorders with an inflammatory component.
REFERENCES:
patent: 3642778 (1972-02-01), Helsley
patent: 3642779 (1972-02-01), Duncan
patent: 3732236 (1973-05-01), Wu
patent: 3941806 (1976-03-01), Welstead, Jr. et al.
patent: 4448784 (1984-05-01), Glamowski et al.
Chemical Abstracts Service: Abstracts Numbers: CA88:89465, 1978; CA86:74390, 1977; CA105:133702, 1986.
Chemical Abstracts Service 109:22954K, 1988.
Chemical Abstracts Service 94:65469V, 1981.
Leuchs, Chem Abstr., Vol. 29, 158 (1935).
Duncan, J. Heterocyclic Chem., Vol. 10, 65-70 (1973).
Gribble, Synthesis, 859-860 (1977).
Gardenhire Eileen M.
Helsley Grover C.
Tegeler John J.
Cintins Marianne M.
Hoechst-Roussel Pharmaceuticals Incorporated
Ikeda Tatsuya
Kilby Scalzo Catherine S.
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