2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544125, 544333, 544361, 546 63, 546 64, 546101, 514185, 5142328, 514253, 514398, 514399, 514400, 514406, 514422, 514286, 514287, A61K 31445, C07D23902

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active

056042469

ABSTRACT:
This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino substituted-isoquino[5,6,7-cd]indazole-6(2H)-ones. These compounds have been shown to have antitumor activity.

REFERENCES:
patent: 5447950 (1995-09-01), Patterson
Showalter, et al J. Med. Chem. (1987), 30 pp. 121-131.
Talbot, et al. J. Clin Oncol. (1991), 9(12) pp. 2141-2147.
Campling, et al in Nephrotoxicity, Peter H. Dekker Bach, ed., (New York 1992) pp. 345-352.

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