2-amino pyrimidine compounds as potent HSP-90 inhibitors

Details 2-amino pyrimidine compounds as potent HSP-90 inhibitors 2-amino pyrimidine compounds as potent HSP-90 inhibitors

2009-08-04

2011-12-20

Murray, Jeffrey (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S280000

Reexamination Certificate

active

08080556

ABSTRACT:
The present invention is directed to compounds of formula (I),or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

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Jolly, C., et al., “Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death,” Journal of the National Cancer Institute, 2000, 1564-1572, vol. 92, No. 19.
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Young, J., et al., “Hsp90: A Specialized but Essential Protein-Folding Tool,” Journal of Cell Biology, 2001, 267-273, vol. 154, No. 2.

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